Exosome-delivered METTL14 drives hypoxia-induced proliferation, metastasis, and glycolysis of breast cancer cells through regulating TRIM16-mediated FGF7 ubiquitination
Hypoxia-induced exosomal METTL14 supports the proliferation, metastasis, and glycolysis of TNBC cells through regulating TRIM16-mediated FGF7 ubiquitination, providing a promising therapeutic target for TNBC treatment.
Authors
- Bo Huang (ORCID: https://orcid.org/0000-0002-1762-9812)
- Zhanjun Chen (ORCID: https://orcid.org/0000-0002-1153-1099)
- Jianshan Lin (ORCID: https://orcid.org/0009-0009-9161-211X)
- Yichao Zhang (ORCID: https://orcid.org/0000-0001-8880-4457)
- Yuanyuan Yuan (ORCID: https://orcid.org/0000-0001-7999-5693)
Institutions
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s13058-025-02099-2
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22