Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial
Dentifrice containing 8.0% arginine showed a statistically significant reduction in caries incidence versus the NaF control, while the 1.5% arginine dentifrice showed equivalence to the NaF control regarding caries reduction. This clinical study confirms that arginine dentifrices are effective alternatives to fluoride in providing anticaries protection.Knowledge Transfer Statement:This study demonstrates that arginine is an efficacious anticaries agent at the examined doses of 1.5% and 8%. Clinicians and consumers can consider this a new caries preventive agent providing choice to people seeking fluoride-free alternatives. Policy makers could leverage these findings to guide oral health initiatives and inform regulations on dentifrice composition, promoting broader access to effective caries prevention methods.
Authors
- Deyu Hu (ORCID: https://orcid.org/0000-0001-7843-371X)
- Maria Ryan (ORCID: https://orcid.org/0000-0002-5049-1392)
- George F. Gao (ORCID: https://orcid.org/0000-0002-3869-615X)
- Guiju Sun (ORCID: https://orcid.org/0000-0001-5969-2185)
- Stephen Lim (ORCID: https://orcid.org/0000-0003-2496-2362)
- Amid I. Ismaïl (ORCID: https://orcid.org/0000-0001-7892-2353)
- Ying Zhong
- Luis R Mateo
- Ran Huang (ORCID: https://orcid.org/0000-0003-3768-6141)
- Zhi Zhou (ORCID: https://orcid.org/0000-0003-2502-7798)
- J. Zimmerman
- Bayardo García-Godoy
- Ping Zhang (ORCID: https://orcid.org/0000-0001-9163-6191)
- Yuchen Zhang (ORCID: https://orcid.org/0000-0002-4442-3668)
- Ze Yang (ORCID: https://orcid.org/0000-0003-4312-1454)
- Yang Li (ORCID: https://orcid.org/0000-0002-6065-4706)
- Wei Yin (ORCID: https://orcid.org/0000-0002-8687-3413)
- YP Zhang
Institutions
- University of Stirling (GB)
- Sichuan University (CN)
- Colgate-Palmolive (United States) (US)
- Statistical Research (United States) (US)
- Temple University (US)
- Xi'an Jiaotong University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- JDR Clinical & Translational Research
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1177/23800844251361471
- Citations
- 1
- Primary Topic
- Dental Health and Care Utilization
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Colgate-Palmolive Company