Brief disruptions in capillary flow result in rapid onset of hypoxia
Our findings indicate that a subset of capillary stalls reach extremely low local oxygen, resulting in transient hypoxia in the surrounding tissue. This reveals a new potential pathological mechanism due to stalled capillary flow.
Authors
- Kıvılcım Kılıç (ORCID: https://orcid.org/0000-0001-7248-8728)
- John T. Giblin (ORCID: https://orcid.org/0000-0002-4483-2971)
- Sava Sakadžić (ORCID: https://orcid.org/0000-0001-6318-1193)
- David A. Boas (ORCID: https://orcid.org/0000-0002-6709-7711)
- Gülce Küreli (ORCID: https://orcid.org/0000-0001-8649-1549)
- Anna Devor (ORCID: https://orcid.org/0000-0002-5143-3960)
- Sreekanth Kura (ORCID: https://orcid.org/0000-0002-8071-3259)
- Baoqiang Li (ORCID: https://orcid.org/0000-0003-2992-3303)
- John Jiang
Institutions
- Boston University (US)
- Harvard University (US)
- Chinese Academy of Sciences (CN)
- Massachusetts General Hospital (US)
- HKUST Shenzhen Research Institute (CN)
- Brain (Germany) (DE)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Shenzhen Institutes of Advanced Technology (CN)
Publication Details
- Journal
- Neurophotonics
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1117/1.nph.12.s2.s22803
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health