Association between neuropsychiatric symptoms and neurodegeneration‐related plasma biomarkers in older adults with and without clinical dementia in the Democratic Republic of the Congo
Identifies neuropsychiatric symptoms as early indicators of Alzheimer's disease (AD) progression. Examines associations between depression and AD biomarkers in preclinical and prodromal stages. Highlights the role of amyloid and tau pathology in depression-related cognitive decline. Discusses implications for early intervention and personalized treatment strategies.
Authors
- Emmanuel Epenge (ORCID: https://orcid.org/0000-0001-5233-0704)
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-1308-646X)
- Álvaro Alonso (ORCID: https://orcid.org/0000-0002-2225-8323)
- Alden L. Gross (ORCID: https://orcid.org/0000-0002-4678-0562)
- Jean N. Ikanga (ORCID: https://orcid.org/0000-0001-8754-733X)
- Saranya Sundaram Patel (ORCID: https://orcid.org/0000-0003-1070-6421)
- Immaculée Kavugho
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Samuel Mampunza (ORCID: https://orcid.org/0000-0002-6875-0487)
- Nathan Tshengele
- Guy Gikelekele
- Caterina Obenauf (ORCID: https://orcid.org/0000-0002-3098-1108)
- Megan Schwinne (ORCID: https://orcid.org/0009-0004-6719-8821)
- Lelo Mananga (ORCID: https://orcid.org/0000-0002-8398-2286)
- Emile Omba Yohe
Institutions
- Johns Hopkins University (US)
- Emory University (US)
- Kinshasa General Hospital (CD)
- University of Kinshasa (CD)
- University Memory and Aging Center (US)
- Amsterdam Neuroscience (NL)
- Université Catholique du Congo (CD)
- Amsterdam University Medical Centers (NL)
- University of Tennessee at Knoxville (US)
- University of North Texas at Dallas (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70530
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University
- National Institutes of Health
- Goizueta Business School, Emory University
- National Institute on Aging
- National Center for Advancing Translational Sciences