Development of mRNA–lipid nanoparticle intrabodies against rickettsial infection
The results demonstrate the feasibility of mRNA-LNP encoding IBs as intracellular probes and a precision therapy addressing underlying cause of obligatory intracellular infection.
Authors
- Yasuko Rikihisa (ORCID: https://orcid.org/0000-0002-1870-5338)
- Qi Yan (ORCID: https://orcid.org/0000-0002-5963-9242)
- Nan Duan
- Mingqun Lin (ORCID: https://orcid.org/0000-0002-9964-5460)
- Stephen Denton (ORCID: https://orcid.org/0000-0003-0779-2031)
- Wenqing Zhang (ORCID: https://orcid.org/0000-0002-2250-4598)
- Yichen Zhong (ORCID: https://orcid.org/0000-0003-3652-1257)
- Yizhou Dong
Institutions
- The Ohio State University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s12929-025-01171-5
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Institutes of Health