Primary Aldosteronism Results in a Decline in Estimated Glomerular Filtration Rate Independent of Blood Pressure: A Case-Control Study
Our study indicates that PA is associated with lower eGFR independent of blood pressure, and the adverse effects might be greater than negative controls or EH patients. Inflammation could be a potential mediator of this detrimental effect. In PA, elevated uric acid may promote crystal formation and glomerular obstruction, contributing to renal dysfunction.
Authors
- Shengzhu Huang (ORCID: https://orcid.org/0000-0002-0956-5097)
- Zengnan Mo
- Yushuang Wei (ORCID: https://orcid.org/0009-0002-5660-1609)
- Lingyu Ye
- Chaoyan Tang
- Mingli Li (ORCID: https://orcid.org/0000-0002-0818-4460)
- Mingjie Xu (ORCID: https://orcid.org/0000-0003-0419-7587)
- B.P. Yan (ORCID: https://orcid.org/0000-0002-6957-6441)
- X. Mai
- Xihui Jin
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Yulin University (CN)
Publication Details
- Journal
- Kidney & Blood Pressure Research
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1159/000547760
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- National Natural Science Foundation of China
- Guangxi Medical University
- Young Scientists Fund