Retrospective Cohort Analysis for Identification of Discordant Rifampicin-resistant Xpert MTB/RIF Assay Results in South Kivu, Eastern Democratic Republic of the Congo, a High Burden Tuberculosis Setting

Our findings indicate that low and very low MTB bacterial loads in sputum are strongly associated with discordant rifampicin resistance results when using Xpert. Further research into underlying mechanisms is needed to establish causality definitively.

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Publication Details

Journal
Clinical Infectious Diseases
Published
2025-08-10
DOI
https://doi.org/10.1093/cid/ciaf451
Citations
1
Primary Topic
Tuberculosis Research and Epidemiology
Type
article
Field-Weighted Citation Impact
1.40
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article

Retrospective Cohort Analysis for Identification of Discordant Rifampicin-resistant Xpert MTB/RIF Assay Results in South Kivu, Eastern Democratic Republic of the Congo, a High Burden Tuberculosis Setting

Jean-Paul Chirambiza, Bertin C Bisimwa, Steven Callens, Leen Rigouts et al.
1 citations
Clinical Infectious Diseases
Tuberculosis Research and Epidemiology
1.40
article

Retrospective Cohort Analysis for Identification of Discordant Rifampicin-resistant Xpert MTB/RIF Assay Results in South Kivu, Eastern Democratic Republic of the Congo, a High Burden Tuberculosis Setting

Jean-Paul Chirambiza, Bertin C Bisimwa, Steven Callens, Leen Rigouts, Bouke C. de Jong, Maja Kiselinova, Isabel Cuella Martin, Andre Nyandwe Hamama Bulabula, Freddy Birembano, Esto Bahizire, Eric Mulume, Michel Kaswa, Patrick DMC Katoto, Valéry Byela, Jean-Claude Semuto Ngabonziza
article en
1 citations

Abstract

Our findings indicate that low and very low MTB bacterial loads in sputum are strongly associated with discordant rifampicin resistance results when using Xpert. Further research into underlying mechanisms is needed to establish causality definitively.

Clinical Infectious DiseasesVol. 82(2)
South African Medical Research Council (ZA), National Tuberculosis Institute (IN), University of Nairobi (KE), Western Cape Department of Health (ZA), University of Antwerp (BE), Stellenbosch University (ZA), Ghent University Hospital (BE), University of Kigali (RW), Ghent University (BE), University of Rwanda (RW), Institut Supérieur de Développement Rural (CD), Institut Supérieur Pédagogique de Bukavu (CD), Université Catholique de Bukavu (CD), Nature Research Centre (LT), Programme National Multisectoriel de Lutte contre le sida (CD), Rwanda Biomedical Center (RW), Instituut voor Tropische Geneeskunde (BE)
Openalex Percentile: Top 17%
Tuberculosis Research and Epidemiology
1.40
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