Retrospective Cohort Analysis for Identification of Discordant Rifampicin-resistant Xpert MTB/RIF Assay Results in South Kivu, Eastern Democratic Republic of the Congo, a High Burden Tuberculosis Setting
Our findings indicate that low and very low MTB bacterial loads in sputum are strongly associated with discordant rifampicin resistance results when using Xpert. Further research into underlying mechanisms is needed to establish causality definitively.
Authors
- Jean-Paul Chirambiza
- Bertin C Bisimwa (ORCID: https://orcid.org/0000-0001-9278-7362)
- Steven Callens (ORCID: https://orcid.org/0000-0002-7245-527X)
- Leen Rigouts (ORCID: https://orcid.org/0000-0003-3301-9480)
- Bouke C. de Jong (ORCID: https://orcid.org/0000-0002-1017-4675)
- Maja Kiselinova (ORCID: https://orcid.org/0000-0002-0683-6840)
- Isabel Cuella Martin (ORCID: https://orcid.org/0000-0001-7543-3386)
- Andre Nyandwe Hamama Bulabula (ORCID: https://orcid.org/0000-0003-2912-4587)
- Freddy Birembano
- Esto Bahizire (ORCID: https://orcid.org/0000-0002-7205-7730)
- Eric Mulume
- Michel Kaswa (ORCID: https://orcid.org/0000-0003-3260-7248)
- Patrick DMC Katoto (ORCID: https://orcid.org/0000-0002-0553-201X)
- Valéry Byela
- Jean-Claude Semuto Ngabonziza (ORCID: https://orcid.org/0000-0002-6075-5603)
Institutions
- South African Medical Research Council (ZA)
- National Tuberculosis Institute (IN)
- University of Nairobi (KE)
- Western Cape Department of Health (ZA)
- University of Antwerp (BE)
- Stellenbosch University (ZA)
- Ghent University Hospital (BE)
- University of Kigali (RW)
- Ghent University (BE)
- University of Rwanda (RW)
- Institut Supérieur de Développement Rural (CD)
- Institut Supérieur Pédagogique de Bukavu (CD)
- Université Catholique de Bukavu (CD)
- Nature Research Centre (LT)
- Programme National Multisectoriel de Lutte contre le sida (CD)
- Rwanda Biomedical Center (RW)
- Instituut voor Tropische Geneeskunde (BE)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1093/cid/ciaf451
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40