White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study

WMHs have a more pronounced impact on neurodegeneration across the LA cohort, with a worse impact on HCs, which also show higher WMHs burden than their US counterparts. This could increase the risk of developing dementia. Moreover, WMHs burden differentially impacts cognition, with a greater negative effect observed in bvFTD subjects from the US. These findings highlight geographic variations in WMHs-related conditions, offering valuable insights for tailored future research.

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Publication Details

Journal
Alzheimer s Research & Therapy
Published
2025-08-12
DOI
https://doi.org/10.1186/s13195-025-01832-5
Citations
1
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
1.47
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article

White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study

Nilton Custodio, Carlos Coronel‐Oliveros, Stefanie Danielle Piña‐Escudero, Leonel Tadao Takada et al.
1 citations
Alzheimer s Research & Therapy
Dementia and Cognitive Impairment Research
1.47
article

White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study

Nilton Custodio, Carlos Coronel‐Oliveros, Stefanie Danielle Piña‐Escudero, Leonel Tadao Takada, Pablo Reyes, Agustín M. Ibáñez, Maria Eugenia Godoy, Sandra Báez, Vicente Medel, Sebastián Moguilner, Juan F. Cardona, Kun Hu, María Isabel Behrens, Joaquín Migeot, Sol Fittipaldi, Maira Okada de Oliveira, Agustina Legaz, Bruce L. Miller, Marcelo Adrián Maito, Francisco Lopera, Raúl González-Gómez, Florencia Altschuler, Enzo Tagliazucchi, Jennifer S. Yokoyama, Martín A. Bruno, Andrea Slachevsky, Hernán Guillermo Hernández, Cecilia González Campo, Josephine Cruzat, Elisa de Paula França Resende, Katherine L. Possin, Adolfo M. García, Diana Matallana, Hernando Santamaria Garcia, José Alberto Ávila‐Funes, Luis Ignacio Brusco, Verónica Canziani, Matias E Fraile-Vazquez, Ana Luisa Sosa Ortíz, Brian Lawlor
article en
1 citations

Abstract

WMHs have a more pronounced impact on neurodegeneration across the LA cohort, with a worse impact on HCs, which also show higher WMHs burden than their US counterparts. This could increase the risk of developing dementia. Moreover, WMHs burden differentially impacts cognition, with a greater negative effect observed in bvFTD subjects from the US. These findings highlight geographic variations in WMHs-related conditions, offering valuable insights for tailored future research.

Alzheimer s Research & TherapyVol. 17(1)
Universidad de Santiago de Chile (CL), Brigham and Women's Hospital (US), Universidad del Desarrollo (CL), Harvard University (US), Consejo Nacional de Investigaciones Científicas y Técnicas (AR), Universidad de Los Andes (CO), University of California, San Francisco (US), Trinity College Dublin (IE), Adolfo Ibáñez University (CL), Pontificia Universidad Javeriana (CO), Universidad de Buenos Aires (AR), Clínica Alemana (CL), Universidad de Antioquia (CO), University of San Andrés (AR), Massachusetts General Hospital (US), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX), Hospital del Salvador (CL), University Memory and Aging Center (US), Instituto de Neurología Cognitiva (AR), Universidad Católica de Cuyo (AR), Hospital Clínico de la Universidad de Chile (CL), Fundación Santa Fe de Bogotá (CO), Institute of Peruvian Studies (PE), Hospital das Clínicas da Universidade Federal de Minas Gerais (BR), Instituto de Neurociencia Biomédica (CL), Institute of Astronomy and Space Physics (AR), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR), Instituto Nacional de Neurología y Neurocirugía (MX), Center for Climate and Resilience Research (CL), Hospital Universitario San Ignacio (CO), Global Brain Health Institute (US), Instituto Cardiovascular de Buenos Aires (AR), University of Chile (CL), Universidad del Valle (CO)
Openalex Percentile: Top 16%
Dementia and Cognitive Impairment Research
1.47
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