White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study
WMHs have a more pronounced impact on neurodegeneration across the LA cohort, with a worse impact on HCs, which also show higher WMHs burden than their US counterparts. This could increase the risk of developing dementia. Moreover, WMHs burden differentially impacts cognition, with a greater negative effect observed in bvFTD subjects from the US. These findings highlight geographic variations in WMHs-related conditions, offering valuable insights for tailored future research.
Authors
- Nilton Custodio (ORCID: https://orcid.org/0000-0002-8025-3272)
- Carlos Coronel‐Oliveros (ORCID: https://orcid.org/0000-0002-9428-2410)
- Stefanie Danielle Piña‐Escudero (ORCID: https://orcid.org/0000-0001-7467-8365)
- Leonel Tadao Takada (ORCID: https://orcid.org/0000-0002-0121-9253)
- Pablo Reyes (ORCID: https://orcid.org/0000-0001-6705-7157)
- Agustín M. Ibáñez (ORCID: https://orcid.org/0000-0001-6758-5101)
- Maria Eugenia Godoy (ORCID: https://orcid.org/0009-0004-5032-5214)
- Sandra Báez (ORCID: https://orcid.org/0000-0003-0875-1709)
- Vicente Medel (ORCID: https://orcid.org/0000-0003-2443-8683)
- Sebastián Moguilner (ORCID: https://orcid.org/0000-0003-1731-8325)
- Juan F. Cardona (ORCID: https://orcid.org/0000-0001-6795-7753)
- Kun Hu (ORCID: https://orcid.org/0000-0003-0350-3132)
- María Isabel Behrens (ORCID: https://orcid.org/0000-0003-0964-426X)
- Joaquín Migeot (ORCID: https://orcid.org/0000-0003-0647-5632)
- Sol Fittipaldi (ORCID: https://orcid.org/0000-0001-7704-3349)
- Maira Okada de Oliveira
- Agustina Legaz (ORCID: https://orcid.org/0000-0002-3753-6824)
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Marcelo Adrián Maito (ORCID: https://orcid.org/0009-0003-5909-7740)
- Francisco Lopera (ORCID: https://orcid.org/0000-0002-5238-0231)
- Raúl González-Gómez (ORCID: https://orcid.org/0000-0003-2341-011X)
- Florencia Altschuler (ORCID: https://orcid.org/0000-0001-6362-963X)
- Enzo Tagliazucchi (ORCID: https://orcid.org/0000-0003-0421-9993)
- Jennifer S. Yokoyama (ORCID: https://orcid.org/0000-0001-7274-2634)
- Martín A. Bruno
- Andrea Slachevsky (ORCID: https://orcid.org/0000-0001-6285-3189)
- Hernán Guillermo Hernández (ORCID: https://orcid.org/0000-0001-8479-6269)
- Cecilia González Campo
- Josephine Cruzat (ORCID: https://orcid.org/0000-0002-3252-8657)
- Elisa de Paula França Resende (ORCID: https://orcid.org/0000-0002-9758-6452)
- Katherine L. Possin (ORCID: https://orcid.org/0000-0002-6623-3793)
- Adolfo M. García (ORCID: https://orcid.org/0000-0002-6936-0114)
- Diana Matallana (ORCID: https://orcid.org/0000-0001-6529-7077)
- Hernando Santamaria Garcia
- José Alberto Ávila‐Funes (ORCID: https://orcid.org/0000-0003-0033-5508)
- Luis Ignacio Brusco (ORCID: https://orcid.org/0000-0002-1846-8686)
- Verónica Canziani
- Matias E Fraile-Vazquez
- Ana Luisa Sosa Ortíz
- Brian Lawlor
Institutions
- Universidad de Santiago de Chile (CL)
- Brigham and Women's Hospital (US)
- Universidad del Desarrollo (CL)
- Harvard University (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Los Andes (CO)
- University of California, San Francisco (US)
- Trinity College Dublin (IE)
- Adolfo Ibáñez University (CL)
- Pontificia Universidad Javeriana (CO)
- Universidad de Buenos Aires (AR)
- Clínica Alemana (CL)
- Universidad de Antioquia (CO)
- University of San Andrés (AR)
- Massachusetts General Hospital (US)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Hospital del Salvador (CL)
- University Memory and Aging Center (US)
- Instituto de Neurología Cognitiva (AR)
- Universidad Católica de Cuyo (AR)
- Hospital Clínico de la Universidad de Chile (CL)
- Fundación Santa Fe de Bogotá (CO)
- Institute of Peruvian Studies (PE)
- Hospital das Clínicas da Universidade Federal de Minas Gerais (BR)
- Instituto de Neurociencia Biomédica (CL)
- Institute of Astronomy and Space Physics (AR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Center for Climate and Resilience Research (CL)
- Hospital Universitario San Ignacio (CO)
- Global Brain Health Institute (US)
- Instituto Cardiovascular de Buenos Aires (AR)
- University of Chile (CL)
- Universidad del Valle (CO)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s13195-025-01832-5
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47