Identification of candidate immunity biomarkers associated with age-related variations in osteoclast activity in a mouse model of orthodontic tooth movement
We identified key molecules that play an important role in orthodontic bone reconstruction by analyzing the differences in immune inflammatory differential gene expression across different age groups. These molecules, which facilitate macrophage migration to the local site and their differentiation into osteoclasts, as well as directly enhance osteoclast differentiation and function, are differentially expressed in young groups, but not in adult groups.
Authors
- Shengfu Huang (ORCID: https://orcid.org/0000-0003-3151-8139)
- Kai Yang (ORCID: https://orcid.org/0000-0002-9712-6333)
- Zhen Chen (ORCID: https://orcid.org/0000-0002-3096-8501)
- Lulu He (ORCID: https://orcid.org/0000-0001-8232-8752)
- Yuhong Li (ORCID: https://orcid.org/0000-0002-6435-2027)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-2968-0682)
Institutions
- Wuhan University (CN)
- Stomatology Hospital (CN)
- Beijing Chuiyangliu Hospital (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s12903-025-06688-7
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China