Autoimmune encephalitis associated with antibodies against α-enolase sequestrated from degenerating retina in retinitis pigmentosa
We describe autoimmune encephalitis caused by autoantibodies against sequestrated retinal antigens in retinitis pigmentosa, which can cross-react with brain tissue. This unique case demonstrates the remote effects of retinitis pigmentosa and an autoimmune pathogenetic pathway that triggered autoimmune encephalitis. Several retinal antigens sequestered into systemic circulation with outer retinal degeneration in retinitis pigmentosa can evoke an immune response and thus produce auto-antibodies that can result in autoimmune encephalitis.
Authors
- Onur İnam (ORCID: https://orcid.org/0000-0002-4726-1190)
- Tongalp H. Tezel (ORCID: https://orcid.org/0000-0002-8416-0452)
- Qun Zeng (ORCID: https://orcid.org/0000-0003-0859-3894)
- Jin Ming Lin
- Sarah F. Wesley
- Androniki Syrrou
Institutions
- City University of New York (US)
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Gazi University (TR)
Publication Details
- Journal
- BMC Ophthalmology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s12886-025-04302-6
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness