Genetic Deletion of <i>Sarm1</i> in Mouse Models of Three Neurological Diseases
While we found no benefit from deleting Sarm1 in these mouse models, they were chosen for their human disease relevance and not for biochemical indicators that SARM1 may be a good target. Thus, SARM1 inhibition may still be effective in other forms of inherited neuropathy, but additional research will be required to identify those candidate subtypes.
Authors
- Courtney L. Hatton (ORCID: https://orcid.org/0000-0002-4387-4782)
- Sara Perkins
- Markus Terrey (ORCID: https://orcid.org/0000-0002-7359-4810)
- Maximiliano Presa (ORCID: https://orcid.org/0000-0002-0160-6528)
- Jennifer Ryan (ORCID: https://orcid.org/0000-0001-7516-9562)
- Robert W. Burgess (ORCID: https://orcid.org/0000-0002-9229-3407)
- Cathleen M. Lutz (ORCID: https://orcid.org/0000-0003-2502-1900)
- Vicki Kennedy
Institutions
- Jackson Laboratory (US)
Publication Details
- Journal
- Journal of the Peripheral Nervous System
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1111/jns.70052
- Citations
- 1
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Charcot-Marie-Tooth Association
- NIH Office of the Director
- National Cancer Institute
- National Institute of Neurological Disorders and Stroke