Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccination Against Hospitalizations and Deaths According to Frailty Score: A Post Hoc Analysis of the DANFLU-1 Randomized Trial
HD-IIV was associated with a lower risk of first and recurrent hospitalizations for pneumonia and influenza compared with SD-IIV and may be preferred for older adults, irrespective of frailty status. The HFRS modified the association of HD-IIV versus SD-IIV with all-cause mortality.
Authors
- Nino Emanuel Landler (ORCID: https://orcid.org/0000-0001-5255-787X)
- Joshua Nealon (ORCID: https://orcid.org/0000-0003-1538-4636)
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Caroline Espersen (ORCID: https://orcid.org/0000-0003-2879-8862)
- Matthew M. Loiacono (ORCID: https://orcid.org/0000-0001-8100-465X)
- Anne Marie Reimer Jensen (ORCID: https://orcid.org/0000-0003-3272-636X)
- Lars Køber (ORCID: https://orcid.org/0000-0002-6635-1466)
- Gunnar Gislason (ORCID: https://orcid.org/0000-0002-0548-402X)
- Jens‐Ulrik Stæhr Jensen (ORCID: https://orcid.org/0000-0003-4036-0521)
- Sandrine Samson (ORCID: https://orcid.org/0000-0001-8365-5093)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Carsten Schade Larsen (ORCID: https://orcid.org/0000-0002-3963-3804)
- Daniel Modin (ORCID: https://orcid.org/0000-0002-7566-0519)
- Kira Hyldekær Janstrup (ORCID: https://orcid.org/0000-0002-0391-5981)
- Melissa K. Andrew (ORCID: https://orcid.org/0000-0001-7514-8972)
- Rebecca C. Harris (ORCID: https://orcid.org/0000-0002-2636-1520)
- Martin Landray (ORCID: https://orcid.org/0000-0001-6646-827X)
- Niklas Dyrby Johansen (ORCID: https://orcid.org/0000-0001-6959-3236)
- Tor Biering‐Sørensen (ORCID: https://orcid.org/0000-0003-4209-2778)
- Pradeesh Sivapalan (ORCID: https://orcid.org/0000-0002-8620-3655)
Institutions
- University of Copenhagen (DK)
- Brigham and Women's Hospital (US)
- Dalhousie University (CA)
- Harvard University (US)
- University of Southern Denmark (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Open Data Institute (GB)
- Sanofi (France) (FR)
- University of Oxford (GB)
- Heart Foundation (US)
- Sanofi (United States) (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1093/infdis/jiaf420
- Citations
- 2
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 2.45