Blood pressure and Alzheimer’s disease biomarkers in cognitively unimpaired adults: a multicenter study
Elevated blood pressure was associated with increased Aβ PET accumulation in cognitively unimpaired individuals. Further research is warranted to elucidate potential mechanisms underlying the negative associations between DBP and CSF biomarkers, which do not reflect the typical AD molecular signature. These findings highlight the relevance of high blood pressure as a potential risk factor for cognitive decline.
Authors
- Abril Martínez-Velasco
- David Vállez García (ORCID: https://orcid.org/0000-0003-3308-3167)
- Gonzalo Sánchez‐Benavides (ORCID: https://orcid.org/0000-0003-3454-800X)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Mahnaz Shekari (ORCID: https://orcid.org/0000-0003-1336-6768)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Maríateresa Buongiorno (ORCID: https://orcid.org/0000-0002-1745-5744)
- Oriol Grau‐Rivera (ORCID: https://orcid.org/0000-0002-4730-5341)
- Gwendlyn Kollmorgen
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Carolina Minguillón (ORCID: https://orcid.org/0000-0002-2782-6908)
- Alejandro de la Sierra (ORCID: https://orcid.org/0000-0002-6548-5497)
- Clara Quijano‐Rubio (ORCID: https://orcid.org/0000-0001-9050-3282)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Mariona Osset-Malla
Institutions
- Roche (Switzerland) (CH)
- Sahlgrenska University Hospital (SE)
- Roche Pharma AG (Germany) (DE)
- University Hospital Mútua de Terrassa (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Pasqual Maragall Foundation (ES)
- UK Dementia Research Institute (GB)
- Barcelonaβeta Brain Research Center (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- University College London (GB)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100304
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- European Federation of Pharmaceutical Industries and Associations
- Ministerio de Ciencia, Innovación y Universidades
- National Institute for Health and Care Research
- University College London
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- Ministerio de Ciencia e Innovación
- UK Dementia Research Institute
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- HORIZON EUROPE Framework Programme
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación