Pancreatic stellate cells promote pancreatic regeneration in chronic pancreatitis via exosomal lncRNA MALAT1-Induced acinar-ductal metaplasia
After PSCs overexpress Gli1, they regulate the expression of RBPJ through lncRNA MALAT1 in exosomes to inhibit ADM pathology, thus inhibiting pancreatic regeneration, providing new insights underlying the molecular mechanisms of pancreatic regeneration in chronic pancreatitis.
Authors
- Wenhui Mo (ORCID: https://orcid.org/0000-0003-4766-9345)
- Weiqi Dai (ORCID: https://orcid.org/0000-0003-0666-8231)
- Congcong Wen (ORCID: https://orcid.org/0000-0001-8413-1697)
- Jinɡjinɡ Li (ORCID: https://orcid.org/0000-0002-7526-5308)
- Wenqiang Xu (ORCID: https://orcid.org/0000-0002-8877-0098)
- Xiaorong Xu (ORCID: https://orcid.org/0000-0002-7668-7238)
- Xuanfu Xu
- Dengyu Han
Institutions
- University of Shanghai for Science and Technology (CN)
- Shanghai Ship and Shipping Research Institute (CN)
- Shanghai Tenth People's Hospital (CN)
- Central Hospital of Putuo District (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1016/j.bbrc.2025.152468
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00