Comparison of plasma p‐tau217/Aβ42, p‐tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease
We tested plasma phosphorylated tau-217 (p-tau217)/amyloid beta (Aβ)<sub>42</sub>, p-tau217, and Aβ42/Aβ40 in diverse training and test sets. In models, race × amyloid PET interactions were not significant. Plasma p-tau217/Aβ42 had the highest accuracy in people who self-identified as Black/African American (pBlack; 0.88) and people who self-identified as White (pWhite; 0.91). Plasma p-tau217/Aβ42 had the lowest proportion of intermediate cases (range = 0.09-0.16). False negatives were more likely to have normal cognition, female sex, and high body mass index.
Authors
- Magdalena Korecka (ORCID: https://orcid.org/0000-0003-3129-8295)
- Mónica Rivera Mindt (ORCID: https://orcid.org/0000-0001-6350-321X)
- Katheryn A Q Cousins (ORCID: https://orcid.org/0000-0003-1879-2766)
- Thomas Francis Tropea (ORCID: https://orcid.org/0000-0003-0766-1496)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Edward B. Lee (ORCID: https://orcid.org/0000-0002-4589-1180)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-5174-3910)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- Susan Landau (ORCID: https://orcid.org/0000-0003-4826-6134)
- Yang Wan (ORCID: https://orcid.org/0009-0003-8542-0900)
- Christopher D. Brown (ORCID: https://orcid.org/0000-0002-3785-5008)
- Ozioma C. Okonkwo (ORCID: https://orcid.org/0009-0009-8764-811X)
- Michael Walter Weiner (ORCID: https://orcid.org/0000-0002-0144-1954)
- Amberley Vulaj
- Yi‐Ju Li (ORCID: https://orcid.org/0000-0001-6996-4834)
Institutions
- University of Wisconsin System (US)
- San Francisco VA Medical Center (US)
- University of Wisconsin–Madison (US)
- Fordham University (US)
- University of California, San Francisco (US)
- University of California System (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Northern California Institute for Research and Education (US)
- University of Pennsylvania (US)
- University of California, Berkeley (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70469
- Citations
- 11
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 16.18
Funders
- University of Pennsylvania
- Alzheimer's Disease Neuroimaging Initiative
- National Institutes of Health
- National Institute on Aging