Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium
Gait analyses reveal older 5×FAD animals display shorter stride length while ambulating. While resting astrocytic calcium activity is increased with age, sex, and genotypes, these results do not explain changes in astrovascular coupling. Only small changes in astrocyte calcium transients and vessel morphology are seen, while the astrocyte-to-vessel correlations (astrovascular coupling) are significantly reduced. Astrocyte network analysis reveals significant reductions in measures of astrocytic communication and activity which are associated with reduced functional vasoreactivity in awake ambulating animals.
Authors
- Christopher M. Norris (ORCID: https://orcid.org/0000-0002-8180-2042)
- Blaine E. Weiss (ORCID: https://orcid.org/0000-0002-1791-295X)
- Pradoldej Sompol (ORCID: https://orcid.org/0000-0002-5160-2509)
- Susan D. Kraner (ORCID: https://orcid.org/0000-0002-1062-4007)
- Ruei‐Lung Lin (ORCID: https://orcid.org/0000-0001-9041-284X)
- Nicholas A. Wright (ORCID: https://orcid.org/0000-0002-5525-3457)
- Stuart Sims (ORCID: https://orcid.org/0000-0002-6327-0927)
- Olivier Thibault (ORCID: https://orcid.org/0000-0002-3548-3466)
- Tom Z. Lu
- Léopoldine B. Galopin
- Jacquelyn E. Rhinehart
Institutions
- University of Kentucky (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70564
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Institutes of Health
- National Institute on Aging