STAT3 expression in brain metastases from breast cancer is correlated with molecular subtype and impacts clinical outcome
This study indicates that STAT3 expression prevails in reactive astrocytes surrounding triple-negative BrM in comparison to HER2-positive and luminal BrM, and these findings mirror those observed in animal models. A high STAT3 expression correlates with higher risk of intracranial recurrence and shorter progression-free survival, particularly in patients with triple-negative BrM.
Authors
- Luca Mangherini (ORCID: https://orcid.org/0000-0001-8675-525X)
- Gloria Mittica
- Joaquim Bosch‐Barrera (ORCID: https://orcid.org/0000-0002-0893-7821)
- Luca Bertero (ORCID: https://orcid.org/0000-0001-9887-7668)
- Neibla Priego (ORCID: https://orcid.org/0000-0002-2587-0104)
- Alessandra Beano
- Paola Cassoni (ORCID: https://orcid.org/0000-0003-1977-7410)
- Francesco Bruno (ORCID: https://orcid.org/0000-0001-8087-5293)
- Manuel Valiente (ORCID: https://orcid.org/0000-0002-0647-7542)
- Diego Garbossa (ORCID: https://orcid.org/0000-0002-2692-7133)
- Alessia Andrea Ricci (ORCID: https://orcid.org/0000-0002-3989-0501)
- Alessia Pellerino (ORCID: https://orcid.org/0000-0003-3243-0059)
- Marinella Mistrangelo
- RENACER
Institutions
- Universitat de Girona (ES)
- Spanish National Cancer Research Centre (ES)
- Institut Català d'Oncologia (ES)
- Neuroscience Institute (IT)
- Institut d'Investigació Biomèdica de Girona (ES)
- Department of Medical Sciences (BY)
- Candiolo Cancer Institute (IT)
- Hospital Universitari de Girona Doctor Josep Trueta (ES)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1093/neuonc/noaf187
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00