METTL3-mediated m <sup>6</sup> A modification promotes intervertebral disc degeneration
This study reveals that targeting METTL3 attenuates IDD progression through the METTL3-m<sup>6</sup>A-miR-338-3p axis, thereby highlighting the therapeutic potential of METTL3 inhibition for IDD. Future studies should prioritize the development of biomaterial delivery systems for METTL3 inhibitors to ensure both therapeutic protection and sustained, site-specific drug release.
Authors
- Congyang Wang (ORCID: https://orcid.org/0000-0002-8053-8251)
- Longao Huang (ORCID: https://orcid.org/0000-0002-0754-4460)
- Hua Jiang
- Feihong Huang (ORCID: https://orcid.org/0000-0001-9829-1050)
- Jianwei Liu (ORCID: https://orcid.org/0000-0003-2965-3518)
- Qingjun Wei (ORCID: https://orcid.org/0000-0002-0748-5608)
- Xiao Liang (ORCID: https://orcid.org/0000-0002-8159-161X)
- Hongyuan Xu (ORCID: https://orcid.org/0000-0001-9294-8349)
- Qinghua Yang (ORCID: https://orcid.org/0009-0007-1802-2004)
Institutions
- Guangxi Medical University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- The Second Nanning People's Hospital (CN)
- Riverside Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1080/07853890.2025.2546670
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China