Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications
This study reveals the distinct origin and diagnostic utility of plasma and urine cfRNA and suggests urine cfRNA is a promising analyte to monitor kidney injury, especially in the context of AKI following ICI treatment.
Authors
- Omary Mzava
- Jerome Ritz (ORCID: https://orcid.org/0000-0001-5526-4669)
- Joan Sesing Lenz
- Iwijn De Vlaminck (ORCID: https://orcid.org/0000-0001-6085-7311)
- Isabel H Gonzalez-Bocco (ORCID: https://orcid.org/0000-0002-2073-092X)
- Matthew P. Cheng (ORCID: https://orcid.org/0000-0002-4867-2063)
- Sophia Koo (ORCID: https://orcid.org/0000-0002-4973-7439)
- Conor Loy (ORCID: https://orcid.org/0000-0001-8816-4293)
- Shruti Gupta (ORCID: https://orcid.org/0000-0002-5747-2151)
- Andrew Bliss
- Liz-Audrey Djomnang Kounatse (ORCID: https://orcid.org/0000-0002-7175-5422)
- Sophia L. Wells
- Tinyi Chu (ORCID: https://orcid.org/0000-0003-3369-6692)
- Lindsey Robert Baden (ORCID: https://orcid.org/0009-0004-1752-1926)
- Kaiwen Chen (ORCID: https://orcid.org/0000-0001-8815-0641)
- E. H. Belcher
- Glory Feyisayo Agun
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Cornell University (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1093/clinchem/hvaf082
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Institutes of Health
- Canadian Institutes of Health Research