From Hypothyroidism to Coronary Heart Disease: Unraveling the Lipid Profile Link: A Mendelian Randomization Study
Our findings suggested a causal link between hypothyroidism and increased CHD risk, likely mediated through changes in HDL-C and apolipoprotein A-I levels. This highlights the importance of monitoring lipid levels in hypothyroid patients and calls for further research to explore these relationships and their implications for prevention and treatment strategies.
Authors
- Shuang Yu (ORCID: https://orcid.org/0000-0001-6843-5914)
- Dide Wu (ORCID: https://orcid.org/0000-0003-3322-445X)
- Boyuan Liu (ORCID: https://orcid.org/0000-0002-4966-7450)
- Shubin Hong (ORCID: https://orcid.org/0000-0001-5377-7727)
- Yanbing Li (ORCID: https://orcid.org/0000-0003-3782-9210)
- Haipeng Xiao (ORCID: https://orcid.org/0000-0002-4188-336X)
- Siyu Long (ORCID: https://orcid.org/0009-0007-3720-1198)
- J M Li
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-06-23
- DOI
- https://doi.org/10.1210/jendso/bvaf108
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- National Natural Science Foundation of China
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund