Unravelling the molecular landscape of polycystic ovary syndrome (PCOS) and role of inflammation through transcriptomics analysis of human ovarian granulosa cells
Therefore, the study highlights that inflammation is a major effector in PCOS, which also fuels obesity, an independent effector that further worsens the PCOS condition. In addition, the genes related to hyperandrogenism, hyperlipidemia, and insulin resistance were also overexpressed in PCOS, exacerbating the condition.
Authors
- Jae‐Ho Shin (ORCID: https://orcid.org/0000-0001-6450-9787)
- Vineet Singh (ORCID: https://orcid.org/0000-0003-2458-3282)
- Kanika Mahra (ORCID: https://orcid.org/0009-0000-6826-6719)
Institutions
- Kyungpook National University (KR)
Publication Details
- Journal
- Genomics & Informatics
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s44342-025-00051-6
- Citations
- 1
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Kyungpook National University
- Korea Basic Science Institute