Ewing’s Sarcoma of the Tongue in a 17-Year-Old Female Patient: A Unique Case Report

Ewing's sarcoma (ES), the second most common primary bone cancer in adolescents, predominantly affects males with a peak incidence at 15 years of age. While extraskeletal presentations are rare, tongue involvement is uncommon, with few cases reported globally. ES typically manifests as a firm swelling, often asymptomatic or accompanied by mild discomfort, and is managed primarily with chemotherapy or surgery. In this report, we present a rare case of a 17-year-old female with extraskeletal ES presenting as progressive swelling on the left side of the tongue. The patient responded impressively to chemotherapy, then was given radiation therapy with complete resolution of the disease. This case highlights the diagnostic and therapeutic challenges of managing such an unusual presentation, contributing valuable insights to the literature, and guiding future care for similar cases.