Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

These changes were related to the broader access to AHAs, and an expanding role for combination therapy, but regimens did not completely parallel the introduction of updated international guidelines. Nevertheless, demographic pressures, clinical inertia and policy-related barriers continue to constrain optimal blood pressure control. Our findings highlight the importance of aligning national prescribing practices with clinical evidence and health system reforms to improve long-term cardio-kidney-metabolic outcomes.