Anti‐Neuroinflammatory and Anti‐Inflammatory Effects of the <scp>NLRP3</scp> Inhibitor <scp>NT</scp> ‐0796 in Subjects with Parkinson's Disease
CNS inhibition of NLRP3 with NT-0796 reduced neuroinflammation over a sustained 28-day dosing period and demonstrates the potential for long-term dosing of NT-0796 in future studies of patients with neurodegeneration. © 2025 NodThera Limited. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Bianca Mullen
- Valérie Reader (ORCID: https://orcid.org/0000-0003-1969-2425)
- Michelle Gorman
- Nicola Lindsay
- Alistair Wheeler
- Zsofia Digby
- Hilary Johnstone
- Peter Thornton (ORCID: https://orcid.org/0000-0002-2489-3507)
- Nicholas Clarke
- Grant Langdon
- Alan P. Watt
- Eric S. Jacobson
Institutions
- Saffron Walden Museum (GB)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1002/mds.30307
- Citations
- 12
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.67