Detection of genome-wide methylation changes in bladder cancer by long-read sequencing of urinary DNA
Even at low-read depths, genome-wide methylation patterns in urinary DNA reflect the presence of BC, potentially permitting rapid, non-invasive and cost-effective BC detection.
Authors
- Richard T. Bryan (ORCID: https://orcid.org/0000-0003-2853-4293)
- Roland Arnold (ORCID: https://orcid.org/0000-0002-7496-7578)
- Kar Keung Cheng (ORCID: https://orcid.org/0000-0002-1516-1857)
- Nicholas David James (ORCID: https://orcid.org/0000-0002-7314-8204)
- Douglas G. Ward (ORCID: https://orcid.org/0000-0002-2328-1445)
- Andrew D. Beggs (ORCID: https://orcid.org/0000-0003-0784-2967)
- Joanne Stockton (ORCID: https://orcid.org/0000-0002-5797-8275)
- Luke Ames (ORCID: https://orcid.org/0009-0004-5126-6746)
- B Tura
- Maurice Petrus Zeegers (ORCID: https://orcid.org/0000-0002-2387-083X)
- Anshita Goel
- Nicholas Tovey
Institutions
- Institute of Cancer Research (GB)
- University College Birmingham (GB)
- Maastricht University (NL)
- University of Birmingham (GB)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s13148-025-01946-5
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research UK