Sloping retina: a novel feature associated with primary open-angle glaucoma in an African ancestry cohort
Associated with risk factors of advanced POAG, sloping presents as a novel feature that warrants further study to determine its mechanisms of development and prevalence in other study populations. Study limitations include: large difference in the number of eyes with and without sloping, potential morphological expressions of other phenotypes posing as sloping, impact of anatomical variability on grading, inherent biases when grading stereoscopic images and absence of a control or glaucoma suspect group. Future research into this phenotype in POAG patients might determine whether sloping retina is the result of or a precursor to glaucomatous damage, leading to a better understanding of POAG.
Authors
- Rebecca Salowe
- Prithvi S. Sankar (ORCID: https://orcid.org/0000-0002-2978-3315)
- Isabel Di Rosa
- Ebenezer Daniel (ORCID: https://orcid.org/0000-0002-2027-2316)
- Yineng Chen (ORCID: https://orcid.org/0000-0003-4808-4525)
- Gui‐Shuang Ying (ORCID: https://orcid.org/0000-0002-5752-1355)
- Roy Lee (ORCID: https://orcid.org/0000-0001-7602-3979)
- Joan M. O’Brien (ORCID: https://orcid.org/0000-0003-4109-2928)
- Amy-Ann Edziah
- Yan Zhu (ORCID: https://orcid.org/0000-0002-5804-8926)
- Victoria Addis
Institutions
- Penn Presbyterian Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- BMJ Open Ophthalmology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1136/bmjophth-2025-002224
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- F. M. Kirby Foundation
- Research to Prevent Blindness
- University of Pennsylvania
- Regeneron Pharmaceuticals
- James N. Kirby Foundation
- National Institutes of Health
- Perelman School of Medicine, University of Pennsylvania
- National Eye Institute