The role of the S1 gene in glandular stomach pathogenesis and tropism of infectious bronchitis virus H120 strain in poultry
Infectious bronchitis virus (IBV) causes high morbidity and mortality worldwide, leading to significant economic losses. While the widespread vaccination with the H120 strain has effectively curbed the spread of IBV, we have discovered that the H120 strain can cause glandular stomach inflammation in chickens. Further research indicates that the S1 gene of the H120 strain determines its tropism for the glandular stomach. Studying the glandular tropism of the H120 strain is crucial for developing effective and safe IBV vaccines.
Authors
- Qingmei Xie (ORCID: https://orcid.org/0000-0001-6537-7798)
- Zhengzhong Xiao
- Yutao Teng (ORCID: https://orcid.org/0009-0000-1530-1808)
- Zhenkai Dai (ORCID: https://orcid.org/0000-0003-3548-8694)
- Guanming Shao
- Jing Zhang (ORCID: https://orcid.org/0000-0001-9604-4400)
- Xinheng Zhang (ORCID: https://orcid.org/0000-0002-3232-4929)
- Keyu Feng
- Jiabei Song
Institutions
- South China Agricultural University (CN)
- Shaoguan University (CN)
- Guangzhou Chemistry (China) (CN)
- Institut de Recherche Vaccinale (FR)
- Ministry of Agriculture (ID)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1128/spectrum.00008-25
- Citations
- 1
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.19