Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells
These findings suggest that epigenetic alterations in the methylation reprogramming of SEs are closely linked to the disruption of transcriptional networks during MuSCs aging. Moreover, our results offer valuable insights into the mechanisms driving SE methylation reprogramming, shedding light on how these epigenetic changes contribute to the molecular processes underlying aging.
Authors
- Anyu Zeng (ORCID: https://orcid.org/0009-0007-8306-6265)
- Xuming Luo
- Baoxi Yu (ORCID: https://orcid.org/0000-0002-5662-1258)
- Zhiqi Zhang (ORCID: https://orcid.org/0000-0001-9086-2453)
- Ming Fu (ORCID: https://orcid.org/0000-0002-5327-780X)
- Hailong Liu (ORCID: https://orcid.org/0000-0002-4983-8555)
- Shuling He
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s13072-025-00619-0
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Guangdong Province
- Medical Science and Technology Foundation of Guangdong Province