Universal off-the-shelf combination immunotherapy using oncolytic viruses to redirect T cell engagers to target solid tumors
Our findings demonstrate that the combination of OV and TCEs offers a promising strategy to drive antitumor immune responses against solid tumors. This approach represents a novel and universal platform currently in phase 1 clinical trial combining TCE therapy with oncolytic virotherapy, overcoming antigen heterogeneity and immunological barriers for the effective treatment of solid tumors.
Authors
- Anthony K. Park (ORCID: https://orcid.org/0000-0001-7692-8874)
- John P. Murad (ORCID: https://orcid.org/0000-0003-0637-2414)
- Yuman Fong (ORCID: https://orcid.org/0000-0002-8934-9959)
- Ryan Urak (ORCID: https://orcid.org/0000-0001-5289-5000)
- Yukiko Yamaguchi (ORCID: https://orcid.org/0009-0007-8461-5000)
- Saul J. Priceman (ORCID: https://orcid.org/0000-0002-8136-2112)
- Xiuli Wang (ORCID: https://orcid.org/0000-0001-5964-4327)
- Stephen J. Forman (ORCID: https://orcid.org/0000-0002-2803-4152)
- Hannah Valencia (ORCID: https://orcid.org/0009-0003-2674-0752)
- Lupita S. Lopez (ORCID: https://orcid.org/0000-0002-9151-6197)
- Seonah Kang
- Shyambabu Chaurasiya (ORCID: https://orcid.org/0000-0002-9543-5458)
- Isabel Monroy (ORCID: https://orcid.org/0000-0003-3959-9324)
- Monil Shah
- Cathy Lu (ORCID: https://orcid.org/0009-0007-0112-4477)
- Wen-Chung Chang
- Leslie Chong
- Colin Cook
- Yuwei Ren
- Jackson Lent-Koop
Institutions
- University of Southern California (US)
- City Of Hope National Medical Center (US)
- USC Norris Comprehensive Cancer Center (US)
- Engeneic (Australia) (AU)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1136/jitc-2024-011051
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Division of Cancer Prevention, National Cancer Institute
- Beckman Research Institute, City of Hope
- Comprehensive Cancer Center, City of Hope