A Proteomic Discovery Study of Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage
In this study, 16 proteins were differentially expressed between good and poor outcome aSAH patients. The proteomic evidence, both on an individual protein and pathway level highlights that inflammation and oxidative injury are associated with the pathophysiology of neurological injury following aSAH. These results support the exploration of treatments targeting these pathways to improve outcome after aSAH.
Authors
- Ben Gaastra (ORCID: https://orcid.org/0000-0002-7517-6882)
- Patrick Holton (ORCID: https://orcid.org/0000-0003-1548-9649)
- Ian Galea (ORCID: https://orcid.org/0000-0002-1268-5102)
- Paul Skipp (ORCID: https://orcid.org/0000-0002-2995-2959)
- Diederik Bulters (ORCID: https://orcid.org/0000-0001-9884-9050)
- Ardalan Zolnourian (ORCID: https://orcid.org/0000-0002-0428-179X)
- Luis Coy (ORCID: https://orcid.org/0000-0001-6466-6408)
Institutions
- Essex Cardiothoracic Centre (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Stroke
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1161/strokeaha.125.051215
- Citations
- 1
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- University of Southampton