Genetically Predict Diet‐derived Antioxidants and Risk of Neurodegenerative Diseases Among Individuals of European Descent: A Mendelian Randomization Study
This MR study indicated a potential protective effect of α-tocopherol and carotene on ALS, vitamin E and ascorbate on PD, and retinol on FTD, while also identifying retinol as a risk factor for ALS and PD. These findings could contribute to the exploration of dietary therapies for NDDs. Further research is necessary to substantiate the potential associations between diet-derived antioxidants or their metabolites and the risk of NDDs in individuals.
Authors
- Qing‐Qing Duan
- Wei‐Ming Su (ORCID: https://orcid.org/0000-0001-9817-9608)
- Kang‐Fu Yin
- Jiang Long (ORCID: https://orcid.org/0000-0001-6571-0589)
- Xia Gao (ORCID: https://orcid.org/0000-0003-0979-9990)
- Yong‐Ping Chen (ORCID: https://orcid.org/0000-0002-5603-4192)
- Xiaojing Gu (ORCID: https://orcid.org/0000-0002-9023-725X)
- Li‐Yi Chi
- Ju‐Rong Li (ORCID: https://orcid.org/0000-0001-8653-545X)
- Wenhao Cai
- Zheng Jiang (ORCID: https://orcid.org/0000-0002-2317-7453)
- Bei Cao
Institutions
- Shanxi Medical University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- First Hospital of Shanxi Medical University (CN)
- Xijing Hospital (CN)
- Dazhou Central Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/brb3.70766
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- National Key Research and Development Program of China