Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories
The degree of stenosis and atherosclerotic burden are significantly higher in the LAD as compared to LCX and RCA, both in epicardial coronary arteries supplying nonischemic or ischemic myocardial territories. In all the three main coronary arteries, both luminal narrowing and plaque burden are independent predictors of ischemia, where the plaque burden is mainly driven by noncalcified plaque. However, many vessels supplying ischemic territories have a relatively low degree of stenosis and plaque burden, especially in the LCX and RCA, limiting the ability of diameter stenosis and PAV to predict myocardial ischemia.
Authors
- Teemu Maaniitty (ORCID: https://orcid.org/0000-0001-5819-4635)
- Antti Saraste (ORCID: https://orcid.org/0000-0003-2488-0893)
- Tanja Kero (ORCID: https://orcid.org/0009-0008-2002-8699)
- Juhani Knuuti (ORCID: https://orcid.org/0000-0003-3156-9593)
- Sarah Bär (ORCID: https://orcid.org/0000-0003-0045-6596)
- Jeroen J. Bax
Institutions
- Leiden University Medical Center (NL)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
Publication Details
- Journal
- Journal of Nuclear Cardiology
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1016/j.nuclcard.2025.102470
- Citations
- 4
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- National Science Foundation
- Foundation for Cardiovascular Research
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Turun Yliopisto
- Sydäntutkimussäätiö