IDO‐1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension
Increased IDO-1 expression in peripheral blood mononuclear cells may drive KP activation and promote pulmonary vascular remodeling in PAH. Epacadostat prevents the development of monocrotaline-induced PH. These findings suggest a novel approach for the treatment of PAH.
Authors
- Karin Tran‐Lundmark (ORCID: https://orcid.org/0000-0001-5973-2618)
- Bence Nagy (ORCID: https://orcid.org/0000-0003-3955-4863)
- Lin Deng (ORCID: https://orcid.org/0000-0002-8322-133X)
- Christophe Guignabert (ORCID: https://orcid.org/0000-0002-8545-4452)
- Carole Phan (ORCID: https://orcid.org/0000-0002-7834-508X)
- Thierry van den Bosch (ORCID: https://orcid.org/0000-0002-7223-4565)
- Lijun Fu (ORCID: https://orcid.org/0000-0003-2501-3740)
- Ly Tu (ORCID: https://orcid.org/0000-0003-2336-5099)
- Zongye Cai (ORCID: https://orcid.org/0000-0002-4898-1907)
- Karin A. Boomars
- Daphne Merkus (ORCID: https://orcid.org/0000-0002-4852-831X)
- Danan Wang (ORCID: https://orcid.org/0000-0002-1181-8831)
- Siyu Tian (ORCID: https://orcid.org/0000-0002-4653-9525)
- Horst Olschewski (ORCID: https://orcid.org/0000-0002-2834-7466)
- Yahong Fu (ORCID: https://orcid.org/0000-0002-4577-032X)
- Yi Yan (ORCID: https://orcid.org/0000-0003-2860-3252)
- Sihao Wang
- Xiaoxuan Li (ORCID: https://orcid.org/0009-0004-9787-5248)
Institutions
- Sigmund Freud Privatuniversität Wien (AT)
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Lund University (SE)
- Medical University of Graz (AT)
- Université Paris-Saclay (FR)
- Erasmus MC (NL)
- Sigmund Freud Privatuniversität - Standort Mailand (IT)
- Ludwig Boltzmann Institute for Lung Vascular Research (AT)
- Shanghai Children's Medical Center (CN)
- Hypertension pulmonaire : physiopathologie et innovation thérapeutique (FR)
- German Centre for Cardiovascular Research (DE)
- German Center for Lung Research (DE)
- Skåne University Hospital (SE)
- Centre of Experimental Medicine of the Slovak Academy of Sciences (SK)
- Second Affiliated Hospital of Zhejiang University (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1161/jaha.124.040896
- Citations
- 3
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.56