Efficacy and Safety of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil Fumarate (TDF) Followed by TAF in Chronic Hepatitis B Patients of East Asian Ethnicity Following 5 Years of Treatment
Through 5 years, rates of virologic suppression were high in East Asian patients treated with TAF or switched from TDF to TAF. TAF and TDF were well tolerated, with improved renal and bone safety observed in patients switching from TDF to TAF.
Authors
- Seng Gee Lim (ORCID: https://orcid.org/0000-0003-0994-4932)
- Wan‐Long Chuang (ORCID: https://orcid.org/0000-0002-2376-421X)
- Leland J. Yee (ORCID: https://orcid.org/0000-0002-0369-5878)
- Mang Ma (ORCID: https://orcid.org/0000-0003-2587-1788)
- Frida Abramov (ORCID: https://orcid.org/0009-0006-7509-1121)
- John F. Flaherty (ORCID: https://orcid.org/0000-0002-4050-8234)
- Marı́a Buti (ORCID: https://orcid.org/0000-0002-0732-3078)
- Scott Fung (ORCID: https://orcid.org/0000-0003-0501-8800)
- Namiki Izumi (ORCID: https://orcid.org/0000-0002-0055-8229)
- Calvin Q. Pan (ORCID: https://orcid.org/0000-0002-3723-6688)
- S. Shalimar (ORCID: https://orcid.org/0000-0003-1247-437X)
- Young‐Suk Lim (ORCID: https://orcid.org/0000-0002-1544-577X)
- Grace Lai–Hung Wong (ORCID: https://orcid.org/0000-0002-2863-9389)
- Edward Gane (ORCID: https://orcid.org/0000-0003-4086-7955)
- Hongyuan Wang (ORCID: https://orcid.org/0000-0002-9330-5940)
- Rajiv Mehta (ORCID: https://orcid.org/0009-0002-7368-4346)
Institutions
- Ulsan College (KR)
- Kaohsiung Medical University (TW)
- University of Auckland (NZ)
- University of Alberta (CA)
- Chinese University of Hong Kong (HK)
- University of Toronto (CA)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- NYU Langone Health (US)
- Surya Hospitals (IN)
- Vall d'Hebron Hospital Universitari (ES)
- Gilead Sciences (United States) (US)
- National University Hospital (SG)
- Musashino Red Cross Hospital (JP)
- Toronto Liver Centre (CA)
- Guangzhou Eighth People's Hospital (CN)
- New York University (US)
- All India Institute of Medical Sciences (IN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1111/apt.70327
- Citations
- 4
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Gilead Sciences