Proteome‐Wide Mendelian Randomization Identifies Natriuretic Peptide‐B and Novel Proteins as Potential Regulators of Pulse Pressure in Humans
Using complementary epidemiological approaches to triangulate findings, our study identifies novel proteins with a putative causal effect on PP. Notably, our findings identify NPPB with high statistical confidence. This may have potentially impactful implications given the current availability of Food and Drug Administration-approved medications to boost NPPB effects.
Authors
- Julio A. Chirinos (ORCID: https://orcid.org/0000-0001-9035-5670)
- James Yarmolinsky (ORCID: https://orcid.org/0000-0003-4371-0873)
- Oday Salman (ORCID: https://orcid.org/0000-0002-8390-1036)
- Bianca Pourmussa (ORCID: https://orcid.org/0000-0003-4763-795X)
- Marie‐Joe Dib (ORCID: https://orcid.org/0000-0001-7591-5684)
- Joe David Azzo (ORCID: https://orcid.org/0009-0000-8161-9611)
- Cameron Beeche (ORCID: https://orcid.org/0000-0002-5781-8810)
- Hamed Tavolinejad (ORCID: https://orcid.org/0000-0002-0244-5914)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Devendra Meena
- Stephen Burgess (ORCID: https://orcid.org/0000-0001-5365-8760)
- Sushrima Gan (ORCID: https://orcid.org/0000-0002-0221-9925)
Institutions
- Palo Alto University (US)
- University of Cambridge (GB)
- Cardiovascular Institute of the South (US)
- Hospital of the University of Pennsylvania (US)
- Palo Alto Institute (US)
- MRC Biostatistics Unit (GB)
- Imperial College London (GB)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1161/jaha.124.037596
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00