Serum Cytokeratin 18 and Fragment as Biomarkers for Severity and Prognosis in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Serum CK-18/CK-18M30 levels at admission were positively correlated with severity and poor prognosis in patients with AECOPD within 3 years. Therefore, serum CK-18 and CK-18M30 concentrations may serve as novel diagnostic and prognostic biomarkers for patients with AECOPD.
Authors
- Hai-Long Miu
- Hui Zhao (ORCID: https://orcid.org/0000-0003-4090-5720)
- Kunbin Qu
- Kai-Shu Ma
- Xiaoxiao Cai (ORCID: https://orcid.org/0000-0002-5654-7414)
- Zhenyu Cheng (ORCID: https://orcid.org/0000-0002-7240-9126)
- Ling Zheng (ORCID: https://orcid.org/0000-0002-6545-4180)
- Jin Yang (ORCID: https://orcid.org/0000-0003-2008-7089)
- Yiqun Wang (ORCID: https://orcid.org/0000-0001-9219-9181)
- Mengxue Liu (ORCID: https://orcid.org/0000-0002-2321-2669)
- Mingyan Liu (ORCID: https://orcid.org/0000-0002-3221-6768)
- Lin Fu
Institutions
- Anhui Medical University (CN)
- Fuyang City People's Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Fourth Affiliated Hospital of Anhui Medical University (CN)
- Fuyang Second People's Hospital (CN)
Publication Details
- Journal
- Lung
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1007/s00408-025-00841-3
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- University Natural Science Research Project of Anhui Province