Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study
Isolated rapid eye movement sleep behavior disorder (iRBD) patients show significant alterations in inter-regional structural connectivity. Global efficiency is reduced in iRBD compared to controls. Areas with increased local efficiency contribute to decreased global efficiency. Altered network efficiency is associated with emerging Parkinsonian features. Higher supramarginal efficiency predicts dementia with Lewy bodies in iRBD.
Authors
- Christina Tremblay (ORCID: https://orcid.org/0000-0002-7747-8147)
- Zsóka Varga (ORCID: https://orcid.org/0000-0001-7296-7382)
- Andrew Vo (ORCID: https://orcid.org/0000-0003-3241-3769)
- Johannes Klein (ORCID: https://orcid.org/0000-0002-8553-2801)
- Ronald B. Postuma (ORCID: https://orcid.org/0000-0002-6468-4734)
- François Rheault (ORCID: https://orcid.org/0000-0002-0097-8004)
- Véronique Daneault (ORCID: https://orcid.org/0000-0002-8950-9043)
- Pauline Dodet (ORCID: https://orcid.org/0000-0002-7078-8345)
- Petr Dušek (ORCID: https://orcid.org/0000-0003-4877-9642)
- Stanislav Mareček (ORCID: https://orcid.org/0009-0004-0773-5373)
- Alexandre Pastor‐Bernier (ORCID: https://orcid.org/0000-0002-8865-6551)
- Isabelle Arnulf (ORCID: https://orcid.org/0000-0002-2240-2516)
- Jean‐François Gagnon (ORCID: https://orcid.org/0000-0002-8125-2925)
- Marie Filiatrault
- Violette Ayral
- Marie Vidailhet
- Stéphane Lehéricy
- Jean-Christophe Corvol
- Liane Desaulniers
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Centre National de la Recherche Scientifique (FR)
- Université de Sherbrooke (CA)
- Inserm (FR)
- Université du Québec à Montréal (CA)
- Charles University (CZ)
- Montreal General Hospital (CA)
- Nuffield Orthopaedic Centre (GB)
- Sorbonne Université (FR)
- University of Oxford (GB)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Hôpital du Sacré-Cœur de Montréal (CA)
- Science Oxford (GB)
- Institut du Cerveau (FR)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70574
- Citations
- 2
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Regeneron Pharmaceuticals
- EU Joint Programme – Neurodegenerative Disease Research
- Alzheimer Society
- W. Garfield Weston Foundation
- Parkinson Society Canada
- National Institute for Health and Care Research
- Department of Health and Social Care
- Parkinson's UK
- European Commission
- Agence Nationale de la Recherche
- Eisai
- Parkinson Canada
- Agentura Pro Zdravotnický Výzkum České Republiky
- National Institutes of Health
- Allergan
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé
- NIHR Oxford Biomedical Research Centre