Progression of Dark-Adapted Visual Fields Over 3 Years in the Rate of Progression in <i>USH2A</i>-Related Retinal Degeneration (RUSH2A) Study
Average yearly change in mean DAVF measures was comparable with the annual change on full-field stimulus testing and faster than in cone-mediated measures. Two-color DAVFs identified rod-mediated function in the majority of patients with USH2A mutations, even though many showed no evidence of rod ERG function.
Authors
- John S. Duncan (ORCID: https://orcid.org/0000-0002-1373-0681)
- Janet K. Cheetham (ORCID: https://orcid.org/0000-0003-4603-5375)
- Michele Melia (ORCID: https://orcid.org/0000-0002-2011-3833)
- Isabelle S. Audo (ORCID: https://orcid.org/0000-0003-0698-5309)
- Rachel M. Huckfeldt (ORCID: https://orcid.org/0000-0002-9220-2261)
- Lassana Samarakoon
- Todd A. Durham (ORCID: https://orcid.org/0000-0002-0363-0329)
- Allison R. Ayala (ORCID: https://orcid.org/0000-0002-1483-7536)
- David G. Birch (ORCID: https://orcid.org/0000-0002-6594-2897)
- Katarína Štingl (ORCID: https://orcid.org/0000-0002-8132-911X)
- Michel Michaelides (ORCID: https://orcid.org/0000-0002-1552-7046)
- Ramiro S. Maldonado (ORCID: https://orcid.org/0000-0002-8440-2095)
- Mark E. Pennesi
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Centre National de la Recherche Scientifique (FR)
- Institut de la Vision (FR)
- Harvard University (US)
- Inserm (FR)
- Oregon Health & Science University (US)
- Duke University (US)
- University of California, San Francisco (US)
- Centre hospitalier national d'ophtalmologie des Quinze-Vingts (FR)
- Foundation Fighting Blindness (US)
- Sorbonne Université (FR)
- Retina Foundation of the Southwest (US)
- Jaeb Center for Health Research (US)
- STZ eyetrial (DE)
- Moorfields Eye Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1167/iovs.66.11.27
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- Sanofi
- Biogen
- Sunovion
- PTC Therapeutics
- Arrowhead Pharmaceuticals
- NightstaRx
- Aldeyra Therapeutics
- Santen
- Astellas Pharma
- H. Lundbeck A/S
- ProQR Therapeutics
- Allergan
- Spark Therapeutics
- National Eye Institute