Targeting PDK4 to mitigate osimertinib-induced cardiotoxicity: Insights into mitochondria-endoplasmic reticulum crosstalk and necroptosis
Our findings identify a novel role for PDK4 in mediating osimertinib-induced cardiomyocyte necroptosis via MAM formation and mitochondrial calcium overload. Targeting the PDK4-BAP31-FIS1 axis may offer a potential therapeutic strategy to mitigate the cardiotoxic effects of osimertinib.
Authors
- Xueyan Lang
- Keyi Jiang
- Yifei Li (ORCID: https://orcid.org/0000-0002-3096-4287)
- Dan Wang (ORCID: https://orcid.org/0000-0002-5934-9085)
- Yue Sun (ORCID: https://orcid.org/0000-0003-4261-2382)
- Jingwen Deng
Institutions
- Guiyang Medical University (CN)
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2025.08.017
- Citations
- 2
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61