Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis
Our study elucidated the molecular mechanism by which moxibustion improved the inflammatory environment and abnormal subchondral bone remodeling in OA mice by activating ACSL1-mediated autophagy, providing the basis and new insights for advancing moxibustion therapy in OA.
Authors
- Lixia Yuan (ORCID: https://orcid.org/0000-0003-4595-0280)
- Binhua Zou (ORCID: https://orcid.org/0000-0003-0731-1525)
- Qing Min Liao (ORCID: https://orcid.org/0000-0003-1012-5301)
- Gang Liu (ORCID: https://orcid.org/0000-0001-8551-741X)
- Xuelan Chen (ORCID: https://orcid.org/0000-0002-8060-6998)
- Liping Fu (ORCID: https://orcid.org/0000-0003-2666-2873)
- Yü Huang (ORCID: https://orcid.org/0000-0002-1277-6784)
Institutions
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s13020-025-01182-2
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province