AFF4 promotes tumor progression and cisplatin resistance by modulating the PTEN/PI3K/AKT/mTOR axis to accelerate glycolysis in lung adenocarcinoma
AFF4 drives metabolic reprogramming, tumor progression, and cisplatin resistance through PTEN-mediated activation of the PI3K/AKT/mTOR signaling pathway, highlighting AFF4 inhibition as a potential therapeutic strategy in LUAD.
Authors
- Qian Dai (ORCID: https://orcid.org/0000-0002-5774-7469)
- Qian Chai (ORCID: https://orcid.org/0000-0002-0938-8166)
- Zongwei Li (ORCID: https://orcid.org/0009-0004-5061-8690)
- Tiantian Jia (ORCID: https://orcid.org/0000-0003-1194-1204)
- Guomeng Li
- Donghui Han (ORCID: https://orcid.org/0000-0002-3742-4355)
- Xueyi Feng
- Yanke Zhang (ORCID: https://orcid.org/0000-0003-4788-8708)
- Tao Xia (ORCID: https://orcid.org/0000-0003-3014-4825)
- Lei Zhao (ORCID: https://orcid.org/0000-0002-2065-4162)
- Xueqin Wang (ORCID: https://orcid.org/0000-0001-8744-850X)
- Yaqian Zhang (ORCID: https://orcid.org/0000-0002-4692-3033)
- Xin‐Dong Wei (ORCID: https://orcid.org/0009-0008-3982-1080)
- Xufeng Yao (ORCID: https://orcid.org/0000-0002-4065-8902)
- Xiaohang Zhang (ORCID: https://orcid.org/0009-0009-6996-0775)
- Yuhao Ma (ORCID: https://orcid.org/0000-0001-6134-8359)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Anhui Mental Health Center (CN)
- Fuyang Second People's Hospital (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s13578-025-01455-1
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Anhui Provincial Key Research and Development Plan