Dissolution Profile of Tosufloxacin Tosylate in Biorelevant Bicarbonate Buffer Containing Sodium Chloride: Precipitation of Hemi-hydrochloride Salt at the Particle Surface
The dissolution of TFLX TS in the NaCl media was suppressed by the precipitation of TFLX 1/2HCl on the particle surface. This is an important case showing that NaCl can suppress the dissolution profile of a non-HCl drug salt at a neutral pH.
Authors
- Kiyohiko Sugano (ORCID: https://orcid.org/0000-0001-5652-1786)
- Hibiki Yamamoto (ORCID: https://orcid.org/0009-0008-6044-8911)
- Nanami Okamoto (ORCID: https://orcid.org/0009-0002-1090-9907)
Institutions
- Ritsumeikan University (JP)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1007/s11095-025-03905-4
- Citations
- 1
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- Ritsumeikan University