Real‐world comparison of first‐line antiseizure monotherapy and the role of age at treatment initiation in newly diagnosed childhood epilepsy: A cohort study from a tertiary center
First-line ASMs showed similar effectiveness in routine pediatric care. Childhood epilepsy treatment outcomes were more strongly influenced by seizure characteristics, neurodevelopmental comorbidities, and timing of initiation than by ASM choice or age. These findings support extrapolating ASM efficacy across pediatric age groups and highlight the value of real-world evidence in treatment decision-making.
Authors
- Dezhi Cao (ORCID: https://orcid.org/0000-0002-7424-8063)
- Guangjun Yu (ORCID: https://orcid.org/0000-0002-7179-0789)
- Jianxiang Liao (ORCID: https://orcid.org/0000-0001-9769-3365)
- Ningshan Li (ORCID: https://orcid.org/0000-0003-1916-2563)
- Huiting Zhang
- Chaoran Yang (ORCID: https://orcid.org/0000-0002-0102-0738)
- Lina Men
- Xiaoying Qiao
Institutions
- Loyola University Chicago (US)
- Chinese University of Hong Kong, Shenzhen (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen Children's Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1111/epi.18607
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shenzhen Graduate School, Peking University
- Sanming Project of Medicine in Shenzhen