Inflammation and Obesity Correlate in Pulmonary Hypertension but Are Associated with Diverging Outcomes
We establish a relationship between CRP and BMI across all-cause PH, although CRP and BMI are associated with diverging clinical outcomes. Inflammation and obesity are relevant phenotypes for consideration in clinical trial design. Understanding their impacts on outcomes is important for clinical practice.
Authors
- Luke Howard (ORCID: https://orcid.org/0000-0003-2822-210X)
- Ze Ming Goh (ORCID: https://orcid.org/0000-0001-8912-8470)
- Stefan Gräf (ORCID: https://orcid.org/0000-0002-1315-8873)
- Chris Wallace (ORCID: https://orcid.org/0000-0001-9755-1703)
- Alexander Rothman (ORCID: https://orcid.org/0000-0002-7847-4500)
- Gerry Coghlan (ORCID: https://orcid.org/0000-0002-3424-5888)
- David Gerard Kiely (ORCID: https://orcid.org/0000-0003-0184-6502)
- Joseph Newman (ORCID: https://orcid.org/0000-0001-5514-0754)
- Stephen John Wort (ORCID: https://orcid.org/0000-0003-4287-1173)
- Colin Church (ORCID: https://orcid.org/0000-0002-4446-0100)
- Priscilla Correa‐Jaque
- Christopher J. Rhodes (ORCID: https://orcid.org/0000-0002-4962-3204)
- Mark R. Toshner (ORCID: https://orcid.org/0000-0002-3969-6143)
- Akshay Gaur (ORCID: https://orcid.org/0009-0004-1760-7519)
- R. Jones (ORCID: https://orcid.org/0000-0002-4551-2320)
- Harm Jan Bogaard (ORCID: https://orcid.org/0000-0001-5371-0346)
- Dharshan Neelam-Naganathan
- Stefano Ghio (ORCID: https://orcid.org/0000-0002-1858-1152)
- Eckart M. D. D. De Bie (ORCID: https://orcid.org/0000-0002-1595-1226)
- Raymond L. Benza (ORCID: https://orcid.org/0000-0001-9627-6236)
- Allan Lawrie (ORCID: https://orcid.org/0000-0003-4192-9505)
- Marc Humbert (ORCID: https://orcid.org/0000-0003-0703-2892)
- Hossein Ardeschir Ghofrani (ORCID: https://orcid.org/0000-0002-2029-4419)
- Thomas Willis (ORCID: https://orcid.org/0000-0001-6138-3496)
- Olivier Sitbon (ORCID: https://orcid.org/0000-0002-1942-1951)
- Gábor Kovács (ORCID: https://orcid.org/0009-0002-0973-8362)
- Wei‐Yu Lin (ORCID: https://orcid.org/0000-0002-9267-7988)
- Karen Sheares
- J. Chan (ORCID: https://orcid.org/0000-0002-2151-8031)
- James Lordan
Institutions
- Mount Sinai Health System (US)
- Infectious Disease Research Institute (US)
- Royal Free London NHS Foundation Trust (GB)
- Medical University of Graz (AT)
- University of Cambridge (GB)
- Universitätsklinikum Gießen und Marburg (DE)
- Université Paris-Saclay (FR)
- The Royal Free Hospital (GB)
- Royal Hallamshire Hospital (GB)
- Freeman Hospital (GB)
- Golden Jubilee National Hospital (GB)
- Pulmonary Hypertension Association (US)
- Victor (Japan) (JP)
- Cambridge School (PT)
- Ludwig Boltzmann Institute for Lung Vascular Research (AT)
- Bridge University (SS)
- Papworth Hospital NHS Foundation Trust (GB)
- Cambridge University Health Partners (GB)
- Universities of Giessen and Marburg Lung Center (DE)
- MRC Biostatistics Unit (GB)
- Policlinico San Matteo Fondazione (IT)
- Amsterdam University Medical Centers (NL)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Bicêtre Hospital (FR)
- University College London (GB)
- Imperial College London (GB)
- Vrije Universiteit Amsterdam (NL)
- Medical Research Council (GB)
- University of Sheffield (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- American Journal of Respiratory and Critical Care Medicine
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1164/rccm.202412-2393oc
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00