Strong Oxide‐Support Interaction Induced Thermal Stabilization of Pt Single Atoms for Durable Catalytic CO Oxidation

Supported metal nanoparticle catalysts often suffer from sintering-induced size-dependent deactivation, limiting their high-temperature applications. Although high-temperature redispersion offers a potential solution, this strategy remains restricted to reducible support materials, severely limiting the selection of catalyst supports with versatile compositions and tunable functionalities. Here, we engineer cationic vacancies at Al₂O₃-La₂O₃ interface via strong oxide-support interaction (SOSI)-driven interfacial reconstruction during calcination. The vacancy-mediated confinement effect dynamically intercepts migrating Pt species, enabling the construction of Al₂O₃-Pt₁-La₂O₃ structure with precisely defined coordination environments. The resulting catalyst achieves complete CO conversion at 145 °C and maintains stability with minimal decline after a 6-h treatment at 1100 °C in air with 10% steam. This interfacial engineering strategy proves universal, as demonstrated by ZrO₂-La₂O₃ counterparts. Our findings break the reducibility dependency in traditional single-atom catalysts (SACs) stabilization by establishing oxide-oxide interface as universal anchoring platforms, which expands the design space of industrial-grade SACs beyond conventional reducible oxides.