Two new cadinane-type sesquiterpene glycosides from <i>Dendrobium findleyanum</i>

Two novel and two previously identified cadinane-type sesquiterpene glycosides, findleyanosides E-F (<b>1</b>-<b>2</b>), balanoindicoside B (<b>3</b>) and pumilaside C (<b>4</b>), were extracted from the <i>Dendrobium findleyanum</i> stems. The establishment of structures was mainly conducted <i>via</i> spectroscopic techniques and by comparing with literature data. Electronic circular dichroism (ECD) computations helped determine the absolute configuration of the novel molecules. All molecules exhibited moderate cytotoxic effects against A-549 human tumour cell lines, with IC<sub>50</sub> values of 15.52, 17.68, 13.85 and 16.64 <i>μ</i>M, respectively.

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Publication Details

Journal
Natural Product Research
Published
2025-08-12
DOI
https://doi.org/10.1080/14786419.2025.2545981
Primary Topic
Biological and pharmacological studies of plants
Type
article
Field-Weighted Citation Impact
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article

Two new cadinane-type sesquiterpene glycosides from Dendrobium findleyanum

Dan Yang, Zhi‐Qing Lin, Zhong‐Quan Cheng
Natural Product Research
Biological and pharmacological studies of plants
article

Two new cadinane-type sesquiterpene glycosides from Dendrobium findleyanum

Dan Yang, Zhi‐Qing Lin, Zhong‐Quan Cheng
article en

Abstract

Two novel and two previously identified cadinane-type sesquiterpene glycosides, findleyanosides E-F (<b>1</b>-<b>2</b>), balanoindicoside B (<b>3</b>) and pumilaside C (<b>4</b>), were extracted from the <i>Dendrobium findleyanum</i> stems. The establishment of structures was mainly conducted <i>via</i> spectroscopic techniques and by comparing with literature data. Electronic circular dichroism (ECD) computations helped determine the absolute configuration of the novel molecules. All molecules exhibited moderate cytotoxic effects against A-549 human tumour cell lines, with IC<sub>50</sub> values of 15.52, 17.68, 13.85 and 16.64 <i>μ</i>M, respectively.

Natural Product Research
Guangdong Medical College (CN), Guangzhou Vocational College of Science and Technology (CN)
Life in Land
Openalex Percentile: Top 77%
Biological and pharmacological studies of plants
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