Oleic acid activates TGFβ-Smad3 signaling to promote ovarian cancer progression
This study provides novel insights into the supporting role of oleic acid in fueling tumor proliferation and metastasis, mechanistically associated with its specific activation of TGFβ-Smad3 signaling. Therapeutically, pharmacological targeting oleic acid synthesis by SCD1 inhibitor emerges as a promising strategy for precision oncology in ovarian cancer management.
Authors
- Yuanjun Tang (ORCID: https://orcid.org/0000-0002-6467-2549)
- Tianhui He (ORCID: https://orcid.org/0000-0002-2835-0702)
- Lixiang Xue (ORCID: https://orcid.org/0000-0003-1507-7193)
- Aosong Zhang
- Zhengyang Guo (ORCID: https://orcid.org/0009-0004-0363-6765)
- Yinjia Li
- Yunyun Guo (ORCID: https://orcid.org/0000-0002-1664-9125)
- Ying Song (ORCID: https://orcid.org/0000-0002-2300-0324)
- Tong Liu (ORCID: https://orcid.org/0000-0002-9111-0226)
- Bing Li (ORCID: https://orcid.org/0000-0002-6951-1373)
- Jiagui Song (ORCID: https://orcid.org/0000-0001-9741-0652)
- Xiao Huo (ORCID: https://orcid.org/0000-0002-1158-2136)
- Yi Qu
Institutions
- Peking University (CN)
- Beijing Jiaotong University (CN)
- Beijing University of Technology (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Ministry of Education (RO)
- Peking University Cancer Hospital (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Peking University Third Hospital (CN)
- National Engineering Research Center for Information Technology in Agriculture (CN)
- Beijing Information Science & Technology University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s13048-025-01763-7
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Peking University
- Peking University Third Hospital