Glymphatic activity in behavioral variant frontotemporal dementia: Link with vascular function and astrocytic activation
Our findings reveal a complex interrelationship among glymphatic, vascular, and inflammatory mechanisms in FTD, highlighting their collective impact on disease severity. Highlight Vascular function, astrocytic activation, and glymphatic activity correlate with each other in frontotemporal dementia. Glymphatic activity mediates the association between vascular function and cognition. Astrocytic activation mediates the association between glymphatic function and cognition. Vascular and glymphatic function synergy drives white matter hyperintensity.
Authors
- Binbin Nie (ORCID: https://orcid.org/0000-0002-8038-7772)
- Jiahui Hou (ORCID: https://orcid.org/0000-0002-3340-8585)
- Liyong Wu (ORCID: https://orcid.org/0000-0002-0684-6248)
- Ailing Yue
- Miao Qu (ORCID: https://orcid.org/0000-0001-6289-9654)
- Haitian Nan (ORCID: https://orcid.org/0000-0002-1185-5464)
- Shaozhen Yan (ORCID: https://orcid.org/0000-0002-0315-7930)
- Jie Lu (ORCID: https://orcid.org/0000-0003-0425-3921)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Hong Ye (ORCID: https://orcid.org/0000-0003-0232-9013)
- Yufei Chen (ORCID: https://orcid.org/0000-0003-0749-7147)
- Qianqian He (ORCID: https://orcid.org/0009-0006-6489-3989)
- Min Chu (ORCID: https://orcid.org/0000-0001-7572-6162)
- Boyang Yu (ORCID: https://orcid.org/0000-0003-4655-3412)
Institutions
- University of Electronic Science and Technology of China (CN)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Beijing Geriatric Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Center for Diagnosis and Research on Alzheimer's Disease (CA)
- Institute of High Energy Physics (AT)
- Key Laboratory of Nuclear Radiation and Nuclear Energy Technology (CN)
- Institute of High Energy Physics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70561
- Citations
- 6
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China