Exercise suppresses osteoclastogenesis by increasing the secretion of muscle-derived L-β-aminoisobutyric acid
Exercise suppresses osteoclastogenesis by enhancing L-BAIBA secretion. These findings provide new insights into the mechanisms underlying the skeletal benefits of exercise and highlight L-BAIBA's therapeutic potential as a novel agent for managing PMOP.
Authors
- Yun-Biao Chen
- Zhiwei Huang (ORCID: https://orcid.org/0000-0002-6312-7434)
- Di-Zheng Wu
- Sheng Yang (ORCID: https://orcid.org/0000-0002-0485-7728)
- Zhaoming Zhong (ORCID: https://orcid.org/0000-0003-1480-028X)
- Hongzhou Li (ORCID: https://orcid.org/0000-0001-8005-1323)
- Guixing Cai
- Jia-Wen Gao (ORCID: https://orcid.org/0000-0002-4426-5559)
- Chen Tu (ORCID: https://orcid.org/0000-0002-7777-4413)
- Jiayi Zhang (ORCID: https://orcid.org/0000-0002-1575-0723)
- Zhihai Cai
- Yong-Peng Yu (ORCID: https://orcid.org/0000-0001-8298-3810)
- Xin Xiang (ORCID: https://orcid.org/0009-0000-1897-7539)
- Guo-Zheng Zhu
- Xinrong He
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jshs.2025.101077
- Citations
- 3
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province