SMUG1 promoted the progression of pancreatic cancer via AKT signaling pathway through binding with FOXQ1
SMUG1 promotes proliferation, migration, gemcitabine resistance, and c-Myc protein stability in pancreatic cancer via protein kinase B signaling through binding with FOXQ1. Furthermore, SMUG1 may be a new potential prognostic and gemcitabine resistance predictor in pancreatic ductal adenocarcinoma.
Authors
- Jin Xu (ORCID: https://orcid.org/0000-0002-2942-8604)
- Zijian Wu (ORCID: https://orcid.org/0000-0003-3497-0884)
- Jie Hua (ORCID: https://orcid.org/0000-0002-0903-814X)
- Si Shi (ORCID: https://orcid.org/0000-0002-6652-0629)
- Jiang Liu (ORCID: https://orcid.org/0000-0002-0654-707X)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-6902-9093)
- Xianjun Yu (ORCID: https://orcid.org/0000-0002-6697-7143)
- Xiaohui Wang (ORCID: https://orcid.org/0000-0003-2690-4481)
- Jingyao Zhang (ORCID: https://orcid.org/0000-0002-8227-9396)
- Wei Wang (ORCID: https://orcid.org/0000-0003-2044-6387)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Cancer Institute (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1097/cm9.0000000000003640
- Citations
- 2
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61